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Navigation: [[Documentation]] / [[Overview]]
Navigation: [[Documentation]] / [[Overview]]
----
----
PMFLib is a toolkit, which implements several methods for free energy calculations employing biased molecular dynamics simulations. While PMFLib provides its own molecular dynamics engine, its usage is rather oriented on coupling with other well-established and optimized molecular dynamics simulations programs.
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==Method Overview==
==Method Overview==


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! Method
! Method
! Abbreviation
! Abbreviation
! ∆G
! ∆A
! ∆H
! ∆U
! -T∆S
! -T∆S
! Multiple-Walkers Approach
! MWA*
! Comment
! Comment
|-
|-
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| Y
| Y
| Y
| Y
| including US-ABF (Umbrella Sampling)
|-
|-
| [[Adaptive Biasing Potential Method]]
| [[Adaptive Biasing Potential Method]]
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| N
| N
| Y
| Y
|
|  
|-
|-
| [[Constrained Dynamics]]
| [[Constrained Dynamics]]
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| N
| N
|
|
|-
| [[Restrained Dynamics]]
| RST
| Y
| N
| N
| N
| US (Umbrella Sampling) via WHAM
|-
|-
| [[Metadynamics]]
| [[Metadynamics]]
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| N
| N
| Y
| Y
|
| including well-tempered metadynamics
|-
|-
| [[Umbrella Sampling - Adaptive Biasing Force Method]]
| [[String Method]]
| US-ABF
| STM
| Y
| Y
| Y
| Y
| N
| N
| N
| N
|
|-
! <center>'''Supporting Method'''</center>
! colspan="6" |
|-
| [[Path Driving]]
| PDRV
| colspan="4" |
|
|-
| [[Collective Variable Monitoring]]
| MON
| colspan="4" |
|
|-
| [[Metric Tensor Correction]]
| MTC
| colspan="4" |
|
|
|}
|}
* MWA = Multiple Walker Approach Extension


==Drivers==
==Drivers==
{| class="wikitable"
! Driver
! Program
! Compatible Versions
! Parallel execution
! Package
! Comment
|-
| SANDER-DYNAMIC
| sander.PMF
| 22, 24
| Y
| [https://ambermd.org AMBER]
|
|-
| PMEMD-DYNAMIC
| pmemd.PMF
| 22, 24
| Y
| [https://ambermd.org AMBER]
| support GPU acceleration
|-
| CATS
| cats
| git master, rolling versioning
| N
| [https://cats.ncbr.muni.cz CATs]
|
|}

Latest revision as of 16:07, 30 May 2026

Navigation: Documentation / Overview


Method Overview

Method Abbreviation ∆A ∆U -T∆S MWA* Comment
Adaptive Biasing Force Method ABF Y Y Y Y including US-ABF (Umbrella Sampling)
Adaptive Biasing Potential Method ABP Y N N Y
Constrained Dynamics CST Y Y Y N
Restrained Dynamics RST Y N N N US (Umbrella Sampling) via WHAM
Metadynamics MTD Y N N Y including well-tempered metadynamics
String Method STM Y N N N
Supporting Method
Path Driving PDRV
Collective Variable Monitoring MON
Metric Tensor Correction MTC
  • MWA = Multiple Walker Approach Extension

Drivers

Driver Program Compatible Versions Parallel execution Package Comment
SANDER-DYNAMIC sander.PMF 22, 24 Y AMBER
PMEMD-DYNAMIC pmemd.PMF 22, 24 Y AMBER support GPU acceleration
CATS cats git master, rolling versioning N CATs