Overview: Difference between revisions

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'''PMFLib''' is a versatile toolkit for performing free energy calculations using various methods based on biased molecular dynamics (MD) simulations. Although PMFLib includes its own MD engine, it is primarily designed to interface with well-established and optimized external MD software. The reference MD engine is sander from the AMBER package.
PMFLib is distributed as free software, and its source code—along with the integrated MD interface—is available for direct download. The compilation process is straightforward and is described in detail in the [[Installation]] section.
==Method Overview==
==Method Overview==


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! Method
! Method
! Abbreviation
! Abbreviation
! ∆G
! ∆A
! ∆H
! ∆U
! -T∆S
! -T∆S
! MWA
! MWA*
! Comment
! Comment
|-
|-
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| Y
| Y
| Y
| Y
| including US-ABF (Umbrella Sampling)
|-
|-
| [[Adaptive Biasing Potential Method]]
| [[Adaptive Biasing Potential Method]]
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| N
| N
| Y
| Y
|
|  
|-
|-
| [[Constrained Dynamics]]
| [[Constrained Dynamics]]
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| N
| N
|
|
|-
| [[Restrained Dynamics]]
| RST
| Y
| N
| N
| N
| US (Umbrella Sampling) via WHAM
|-
|-
| [[Metadynamics]]
| [[Metadynamics]]
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| N
| N
| Y
| Y
|
| including well-tempered metadynamics
|-
| [[Umbrella Sampling - Adaptive Biasing Force Method]]
| US-ABF
| Y
| Y
| Y
| N
|
|-
|-
| [[String Method]]
| [[String Method]]
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|-
|-
! <center>'''Supporting Method'''</center>
! <center>'''Supporting Method'''</center>
! colspan="6" |  
! colspan="6" |
|-
| [[Path Driving]]
| PDRV
| colspan="4" |
|  
|-
|-
| [[Collective Variable Monitoring]]
| [[Collective Variable Monitoring]]
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|
|
|-
|-
| [[Path Driving]]
| [[Metric Tensor Correction]]
| PDRV
| MTC
| colspan="4" |
|
|-
| [[Restrained Dynamics]]
| RST
| colspan="4" |  
| colspan="4" |  
|
|
|}
|}
* MWA = Multiple Walker Approach Extension


==Drivers==
==Drivers==

Latest revision as of 16:07, 30 May 2026

Navigation: Documentation / Overview


Method Overview

Method Abbreviation ∆A ∆U -T∆S MWA* Comment
Adaptive Biasing Force Method ABF Y Y Y Y including US-ABF (Umbrella Sampling)
Adaptive Biasing Potential Method ABP Y N N Y
Constrained Dynamics CST Y Y Y N
Restrained Dynamics RST Y N N N US (Umbrella Sampling) via WHAM
Metadynamics MTD Y N N Y including well-tempered metadynamics
String Method STM Y N N N
Supporting Method
Path Driving PDRV
Collective Variable Monitoring MON
Metric Tensor Correction MTC
  • MWA = Multiple Walker Approach Extension

Drivers

Driver Program Compatible Versions Parallel execution Package Comment
SANDER-DYNAMIC sander.PMF 22, 24 Y AMBER
PMEMD-DYNAMIC pmemd.PMF 22, 24 Y AMBER support GPU acceleration
CATS cats git master, rolling versioning N CATs